Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance
نویسندگان
چکیده
منابع مشابه
JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis
Trophic factor deprivation (TFD) activates c-Jun N-terminal kinases (JNKs), culminating in coordinate AP1-dependent transactivation of the BH3-only BCL-2 proteins BIM(EL) and HRK, which in turn are critical for BAX-dependent cytochrome c release, caspase activation, and apoptosis. Here, we report that TFD caused not only induction but also phosphorylation of BIM(EL). Mitochondrially localized J...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2018
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201745235